Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study
Identifieur interne : 001A87 ( Main/Exploration ); précédent : 001A86; suivant : 001A88Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study
Auteurs : Francesca Mattei [France] ; Silvia Liverani [Royaume-Uni] ; Florence Guida [Royaume-Uni] ; Mireille Matrat [France] ; Sylvie Cenée [France] ; Lamiae Azizi [Australie] ; Gwenn Menvielle [France] ; Marie Sanchez [France] ; Corinne Pilorget [France] ; Bénédicte Lapôtre-Ledoux [France] ; Danièle Luce [France] ; Sylvia Richardson [Royaume-Uni] ; Isabelle Stücker [France]Source :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Adénocarcinome (), Adénocarcinome (épidémiologie), Composés chimiques organiques (effets indésirables), Entretiens comme sujet, Exposition professionnelle (effets indésirables), Facteurs de risque, France (épidémiologie), Humains, Maladies professionnelles (), Maladies professionnelles (anatomopathologie), Maladies professionnelles (épidémiologie), Mâle, Solvants (effets indésirables), Sujet âgé, Théorème de Bayes, Tumeurs du poumon (), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (épidémiologie), Tumeurs épidermoïdes (), Tumeurs épidermoïdes (épidémiologie), Études cas-témoins.
- MESH :
- anatomopathologie : Maladies professionnelles, Tumeurs du poumon.
- effets indésirables : Composés chimiques organiques, Exposition professionnelle, Solvants.
- épidémiologie : Adénocarcinome, France, Maladies professionnelles, Tumeurs du poumon, Tumeurs épidermoïdes.
- Adulte, Adulte d'âge moyen, Adénocarcinome, Entretiens comme sujet, Facteurs de risque, Humains, Maladies professionnelles, Mâle, Sujet âgé, Théorème de Bayes, Tumeurs du poumon, Tumeurs épidermoïdes, Études cas-témoins.
English descriptors
- KwdEn :
- Adenocarcinoma (chemically induced), Adenocarcinoma (epidemiology), Adult, Aged, Bayes Theorem, Case-Control Studies, France (epidemiology), Humans, Interviews as Topic, Lung Neoplasms (chemically induced), Lung Neoplasms (epidemiology), Lung Neoplasms (pathology), Male, Middle Aged, Neoplasms, Squamous Cell (chemically induced), Neoplasms, Squamous Cell (epidemiology), Occupational Diseases (chemically induced), Occupational Diseases (epidemiology), Occupational Diseases (pathology), Occupational Exposure (adverse effects), Organic Chemicals (adverse effects), Risk Factors, Solvents (adverse effects).
- MESH :
- chemical , adverse effects : Organic Chemicals, Solvents.
- adverse effects : Occupational Exposure.
- chemically induced : Adenocarcinoma, Lung Neoplasms, Neoplasms, Squamous Cell, Occupational Diseases.
- epidemiology : Adenocarcinoma, France, Lung Neoplasms, Neoplasms, Squamous Cell, Occupational Diseases.
- pathology : Lung Neoplasms, Occupational Diseases.
- Adult, Aged, Bayes Theorem, Case-Control Studies, Humans, Interviews as Topic, Male, Middle Aged, Risk Factors.
Abstract
The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used
The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos.
We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case–control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression.
After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters.
Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.
Url:
DOI: 10.1136/oemed-2015-103177
PubMed: 26911986
PubMed Central: 4893113
Affiliations:
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Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liverani, Silvia" sort="Liverani, Silvia" uniqKey="Liverani S" first="Silvia" last="Liverani">Silvia Liverani</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Mathematics</addr-line>,<institution>Brunel University London</institution>,<addr-line>Uxbridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>MRC Biostatistics Unit</addr-line>,<institution>Cambridge Institute of Public Health, Cambridge Biomedical Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Imperial College London, MRC-PHE Centre for Environment and Health, School of Public Health</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Matrat, Mireille" sort="Matrat, Mireille" uniqKey="Matrat M" first="Mireille" last="Matrat">Mireille Matrat</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Faculty of Medicine IFR 10</addr-line>,<institution>University Paris Est-Créteil</institution>,<addr-line>Créteil</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cenee, Sylvie" sort="Cenee, Sylvie" uniqKey="Cenee S" first="Sylvie" last="Cenée">Sylvie Cenée</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Azizi, Lamiae" sort="Azizi, Lamiae" uniqKey="Azizi L" first="Lamiae" last="Azizi">Lamiae Azizi</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>University of Sydney, Sydney School of Public Health, Screening an Evaluation Test Program</institution>,<addr-line>Sydney, New South Wales</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Menvielle, Gwenn" sort="Menvielle, Gwenn" uniqKey="Menvielle G" first="Gwenn" last="Menvielle">Gwenn Menvielle</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of social epidemiology</addr-line>,<institution>INSERM, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of social epidemiology</addr-line>,<institution>Sorbonne University, UPMC University of Paris 06, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pilorget, Corinne" sort="Pilorget, Corinne" uniqKey="Pilorget C" first="Corinne" last="Pilorget">Corinne Pilorget</name><affiliation wicri:level="1"><nlm:aff id="af9"><institution>French Institute for Public Health Surveillance</institution>,<addr-line>Saint-Maurice</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Epidemiological research and surveillance unit in transport, occupation and environment</addr-line>,<institution>Claude Bernard Lyon1 University</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lapotre Ledoux, Benedicte" sort="Lapotre Ledoux, Benedicte" uniqKey="Lapotre Ledoux B" first="Bénédicte" last="Lapôtre-Ledoux">Bénédicte Lapôtre-Ledoux</name><affiliation wicri:level="1"><nlm:aff id="af11"><institution>Somme Cancer Registry</institution>,<addr-line>Amiens</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luce, Daniele" sort="Luce, Daniele" uniqKey="Luce D" first="Danièle" last="Luce">Danièle Luce</name><affiliation wicri:level="1"><nlm:aff id="af12"><institution>INSERM, U 1085_IRSET</institution>,<addr-line>Pointe-à-Pitre</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>University of Rennes 1</institution>,<addr-line>Rennes</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richardson, Sylvia" sort="Richardson, Sylvia" uniqKey="Richardson S" first="Sylvia" last="Richardson">Sylvia Richardson</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>MRC Biostatistics Unit</addr-line>,<institution>Cambridge Institute of Public Health, Cambridge Biomedical Campus</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stucker, Isabelle" sort="Stucker, Isabelle" uniqKey="Stucker I" first="Isabelle" last="Stücker">Isabelle Stücker</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Université Paris Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM</institution>,<addr-line>Villejuif</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Occupational and Environmental Medicine</title><idno type="ISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (chemically induced)</term><term>Adenocarcinoma (epidemiology)</term><term>Adult</term><term>Aged</term><term>Bayes Theorem</term><term>Case-Control Studies</term><term>France (epidemiology)</term><term>Humans</term><term>Interviews as Topic</term><term>Lung Neoplasms (chemically induced)</term><term>Lung Neoplasms (epidemiology)</term><term>Lung Neoplasms (pathology)</term><term>Male</term><term>Middle Aged</term><term>Neoplasms, Squamous Cell (chemically induced)</term><term>Neoplasms, Squamous Cell (epidemiology)</term><term>Occupational Diseases (chemically induced)</term><term>Occupational Diseases (epidemiology)</term><term>Occupational Diseases (pathology)</term><term>Occupational Exposure (adverse effects)</term><term>Organic Chemicals (adverse effects)</term><term>Risk Factors</term><term>Solvents (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénocarcinome ()</term><term>Adénocarcinome (épidémiologie)</term><term>Composés chimiques organiques (effets indésirables)</term><term>Entretiens comme sujet</term><term>Exposition professionnelle (effets indésirables)</term><term>Facteurs de risque</term><term>France (épidémiologie)</term><term>Humains</term><term>Maladies professionnelles ()</term><term>Maladies professionnelles (anatomopathologie)</term><term>Maladies professionnelles (épidémiologie)</term><term>Mâle</term><term>Solvants (effets indésirables)</term><term>Sujet âgé</term><term>Théorème de Bayes</term><term>Tumeurs du poumon ()</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (épidémiologie)</term><term>Tumeurs épidermoïdes ()</term><term>Tumeurs épidermoïdes (épidémiologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Organic Chemicals</term><term>Solvents</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies professionnelles</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Adenocarcinoma</term><term>Lung Neoplasms</term><term>Neoplasms, Squamous Cell</term><term>Occupational Diseases</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Composés chimiques organiques</term><term>Exposition professionnelle</term><term>Solvants</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Adenocarcinoma</term><term>France</term><term>Lung Neoplasms</term><term>Neoplasms, Squamous Cell</term><term>Occupational Diseases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung Neoplasms</term><term>Occupational Diseases</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Adénocarcinome</term><term>France</term><term>Maladies professionnelles</term><term>Tumeurs du poumon</term><term>Tumeurs épidermoïdes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Bayes Theorem</term><term>Case-Control Studies</term><term>Humans</term><term>Interviews as Topic</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénocarcinome</term><term>Entretiens comme sujet</term><term>Facteurs de risque</term><term>Humains</term><term>Maladies professionnelles</term><term>Mâle</term><term>Sujet âgé</term><term>Théorème de Bayes</term><term>Tumeurs du poumon</term><term>Tumeurs épidermoïdes</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used <italic>simultaneously</italic>, it is difficult to assess the role of individual substances.</p></sec><sec><title>Objectives</title><p>The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos.</p></sec><sec><title>Methods</title><p>We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case–control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression.</p></sec><sec><title>Results</title><p>After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters.</p></sec><sec><title>Conclusions</title><p>Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Binder Foucard, F" uniqKey="Binder Foucard F">F Binder-Foucard</name></author><author><name sortKey="Belot, A" uniqKey="Belot A">A Belot</name></author><author><name sortKey="Delafosse, P" uniqKey="Delafosse P">P Delafosse</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Imbernon, E" uniqKey="Imbernon E">E Imbernon</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hayes, Rb" uniqKey="Hayes R">RB 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uniqKey="James D">DJ James</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farris, Gm" uniqKey="Farris G">GM Farris</name></author><author><name sortKey="Everitt, Ji" uniqKey="Everitt J">JI Everitt</name></author><author><name sortKey="Irons, Rd" uniqKey="Irons R">RD Irons</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mehlman, Ma" uniqKey="Mehlman M">MA Mehlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maltoni, C" uniqKey="Maltoni C">C Maltoni</name></author><author><name sortKey="Conti, B" uniqKey="Conti B">B Conti</name></author><author><name sortKey="Perino, G" uniqKey="Perino G">G Perino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stoner, Gd" uniqKey="Stoner G">GD Stoner</name></author><author><name sortKey="Conran, Pb" uniqKey="Conran P">PB Conran</name></author><author><name sortKey="Greisiger, Ea" 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S" first="Sylvie" last="Cenée">Sylvie Cenée</name><name sortKey="Lapotre Ledoux, Benedicte" sort="Lapotre Ledoux, Benedicte" uniqKey="Lapotre Ledoux B" first="Bénédicte" last="Lapôtre-Ledoux">Bénédicte Lapôtre-Ledoux</name><name sortKey="Luce, Daniele" sort="Luce, Daniele" uniqKey="Luce D" first="Danièle" last="Luce">Danièle Luce</name><name sortKey="Luce, Daniele" sort="Luce, Daniele" uniqKey="Luce D" first="Danièle" last="Luce">Danièle Luce</name><name sortKey="Matrat, Mireille" sort="Matrat, Mireille" uniqKey="Matrat M" first="Mireille" last="Matrat">Mireille Matrat</name><name sortKey="Matrat, Mireille" sort="Matrat, Mireille" uniqKey="Matrat M" first="Mireille" last="Matrat">Mireille Matrat</name><name sortKey="Menvielle, Gwenn" sort="Menvielle, Gwenn" uniqKey="Menvielle G" first="Gwenn" last="Menvielle">Gwenn Menvielle</name><name sortKey="Menvielle, Gwenn" sort="Menvielle, Gwenn" uniqKey="Menvielle G" first="Gwenn" last="Menvielle">Gwenn Menvielle</name><name sortKey="Pilorget, Corinne" sort="Pilorget, Corinne" uniqKey="Pilorget C" first="Corinne" last="Pilorget">Corinne Pilorget</name><name sortKey="Pilorget, Corinne" sort="Pilorget, Corinne" uniqKey="Pilorget C" first="Corinne" last="Pilorget">Corinne Pilorget</name><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><name sortKey="Stucker, Isabelle" sort="Stucker, Isabelle" uniqKey="Stucker I" first="Isabelle" last="Stücker">Isabelle Stücker</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Liverani, Silvia" sort="Liverani, Silvia" uniqKey="Liverani S" first="Silvia" last="Liverani">Silvia Liverani</name></noRegion><name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name><name sortKey="Liverani, Silvia" sort="Liverani, Silvia" uniqKey="Liverani S" first="Silvia" last="Liverani">Silvia Liverani</name><name sortKey="Richardson, Sylvia" sort="Richardson, Sylvia" uniqKey="Richardson S" first="Sylvia" last="Richardson">Sylvia Richardson</name></country><country name="Australie"><noRegion><name sortKey="Azizi, Lamiae" sort="Azizi, Lamiae" uniqKey="Azizi L" first="Lamiae" last="Azizi">Lamiae Azizi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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